Explore a comprehensive guide to antiphospholipid syndrome with Meri Sehat. Understand the condition and its impact on health.

Antiphospholipid Syndrome – A Comprehensive Guide!

APS is characterized by a heightened propensity to form blood clots (thromboses) in the bloodstream.

Introduction

Have you ever heard of a disorder that makes your blood go rogue and starts attacking your own body? That&#39;s exactly what happens in <a href="https://merisehat.pk/disease/antiphospholipid-syndrome">antiphospholipid syndrome (APS)</a> &ndash; an autoimmune condition where your immune system goes haywire and starts attacking the body&rsquo;s own tissues and organs. 

This causes all sorts of chaos, including blood clots, miscarriages, and even strokes. It&#39;s like having a really bad roommate in your bloodstream &ndash; always causing trouble and making life more complicated than it needs to be.

APS is characterized by a heightened propensity to form blood clots (thromboses) in the bloodstream. This tendency towards blood clotting, referred to as thrombophilia, can result in the formation of clots in various blood vessels throughout the body. 

It is a relatively uncommon condition that is estimated to affect about 1 in 2,000 individuals<a href="#accordion">[8]</a>. Despite this, estimates suggest that it may be responsible for up to 1% of all thrombotic events<a href="#accordion">[8]</a>. 

The condition appears to be particularly prevalent in young people who have suffered a stroke, with an estimated 20% of stroke patients under the age of 50 having APS<a href="#accordion">[8]</a>. 

Similarly, it is estimated that 10-15% of individuals with systemic lupus erythematosus may have this condition<a href="#accordion">[8]</a>. 

It is important to note that antiphospholipid syndrome appears to affect women more frequently than men, with approximately 70% of those diagnosed with the condition being female<a href="#accordion">[1]</a> <a href="#accordion">[8]</a>. 10-15% of women with a history of recurrent miscarriages have it<a href="#accordion">[8]</a>. 
&nbsp;

Understanding  Antiphospholipid Syndrome in women

The classification of APS is primarily based on a set of clinical criteria used in the diagnosis of the disorder:

<ul>
	<li>Primary Antiphospholipid Syndrome: Occurs in patients without any underlying systemic disease.</li>
	<li>Secondary Antiphospholipid Syndrome: Occurs in patients with an underlying autoimmune disease, such as systemic lupus erythematosus or other connective tissue diseases.</li>
	<li>Catastrophic Antiphospholipid Syndrome: A rare and severe form of the syndrome that is characterized by rapidly progressive microvascular thrombosis leading to multiorgan failure. 
	&nbsp;</li>
</ul>

The primary clinical consequence of antiphospholipid syndrome is a tendency to both venous and arterial thrombosis. However, thrombotic events in a specific patient with APS tend to segregate into venous or arterial. 

In a review of 50 patients with catastrophic APS, the mortality rate was 50%, with cardiac disorders and respiratory failure from adult respiratory distress syndrome being the primary causes of death<a href="#accordion">[7]</a>. 
&nbsp;

Some common signs and symptoms of APS include:

<ul>
	<li>Deep Vein Thrombosis (DVT): This is a blood clot that forms in a deep vein, often in the leg. It can cause swelling, pain, and redness.</li>
	<li>Pulmonary Embolism (PE): This is a blood clot that travels to the lungs and can cause chest pain, shortness of breath, and a rapid heartbeat.</li>
	<li>Stroke: APS can increase the risk of stroke, which can cause sudden weakness or numbness on one side of the body, trouble speaking, and vision changes.</li>
	<li>Thrombocytopenia: This is a condition where there is a low level of platelets in the blood, which can cause easy bruising and bleeding.</li>
	<li>Heart Attack: APS can increase the risk of heart attack, which can cause chest pain, shortness of breath, and a rapid heartbeat.</li>
	<li>Recurrent Miscarriages: APS can increase the risk of pregnancy-related complications, including recurrent miscarriages.</li>
	<li>Rash: A red rash with a lacy, net-like appearance can develop.</li>
	<li>Neurological Symptoms: This includes dementia, chronic headaches, and seizures as blood flow to part of the brain is blocked. 
	&nbsp;</li>
</ul>

Seek emergency care if you experience any of the aforementioned signs and symptoms of stroke, deep vein thrombosis, or pulmonary embolism. This includes swelling or pain in the arm or leg, chest pain, coughing up blood, sudden numbness, severe headache, and difficulty understanding speech.

You should also contact a doctor if you have unexplained abdominal pain, unexplained bleeding from gums or nose, bright-red vomit, tarry or bright-red stool, and an unusually heavy period. 
&nbsp;

The exact cause of antiphospholipid syndrome (APS) is not well understood, but it is believed to be an autoimmune disorder. The body&#39;s immune system mistakenly attacks phospholipids, which are important components of cell membranes, leading to the formation of antiphospholipid antibodies that can cause blood clots and increase the risk of pregnancy-related complications. 
&nbsp;

Several factors contribute to the development of APS, including:

<ul>
	<li>Genetics: Some studies have suggested that there may be a genetic component to APS, as the condition is more common in some families. However, it does not have a clear pattern of inheritance.<a href="#accordion">[3]</a></li>
	<li>Infections: Certain infections, such as syphilis, HIV, and hepatitis C, have been associated with the development of APS. Bacterial infections, such as leptospirosis, may also cause APS.</li>
	<li>Other autoimmune disorders: APS is often associated with other autoimmune disorders, such as systemic lupus erythematosus (SLE).</li>
	<li>Medications: Certain medications, such as hydralazine, procainamide, quinidine, propranolol, quinine, amoxicillin, phenytoin, and oral contraceptives have been linked to the development of APS.</li>
	<li>Environmental factors: Exposure to certain environmental factors, such as chemicals and toxins.</li>
	<li>Others: Surgery, prolonged inactivity, pregnancy, hypertension, smoking, and obesity are additional risk factors to trigger blood clotting and, therefore, APS<a href="#accordion">[1]</a> <a href="#accordion">[4]</a>. 
	&nbsp;</li>
</ul>

APS can be a challenging condition to diagnose, as its symptoms are similar to other conditions and there is no single test that can confirm the diagnosis. 
&nbsp;

<h5>Antiphospholipid Antibody Testing&nbsp;</h5>

This test measures the level of antiphospholipid antibodies in the blood. Antiphospholipid antibodies are a type of autoantibody that target phospholipids, which are a component of cell membranes.<a href="#accordion">[6]</a> 
&nbsp;

<ul>
	<li>The False-Positive Syphilis Test - The false-positive syphilis test in individuals with lupus was one of the initial indications of antiphospholipid antibodies and hence, this false-positive syphilis test was the initial recognized test for antiphospholipid antibodies. With progress in the field of medicine it is now understood that antiphospholipid antibodies can be present without causing a false-positive syphilis test, and vice versa. While not all past medical studies link the false-positive test to an increased risk of blood clots, certain studies, such as the Johns Hopkins Lupus Cohort, suggest a potential association.</li>
	<li>The Lupus Anticoagulant - is a misnomer because it actually increases the ability of the blood to clot and it&#39;s not necessary for patients with this antibody to have lupus. It can be detected with coagulation tests, including the activated partial thromboplastin time (aPTT) and the modified Russell viper venom time (RVVT), among others.</li>
	<li>The Anticardiolipin Antibody - was identified as a major component of the false-positive syphilis test in the 1980s, and was found to be associated with recurrent thrombosis and pregnancy losses. There are different classes (isotypes) of anticardiolipin antibodies &ndash; IgG, IgM, and IgA, with IgG being the type most associated with complications.</li>
	<li>Anti-Beta2 Glycoprotein 1 - Beta2 glycoprotein 1 is the protein in the body to which anticardiolipin antibodies bind, and it is also possible to measure antibodies to beta2 glycoprotein 1. Detection of anti-&szlig;2 GPI is not yet part of routine testing done for patients with an increased likelihood of blood clot 
	&nbsp;</li>
</ul>

<h5>Pregnancy-Related Medical Assessment</h5>

If you are diagnosed with APS through blood tests, your medical history will be reviewed to check for previous symptoms related to APS. A diagnosis of APS can usually be confirmed if you have a history of one or more blood clots and also experienced at least one of the following<a href="#accordion">[3]</a>:

<ul>
	<li>Unexplained late miscarriage after 10 weeks of pregnancy</li>
	<li>Premature birth before 34 weeks of pregnancy</li>
	<li>Three or more unexplained early miscarriages before 10 weeks of pregnancy. 
	&nbsp;</li>
</ul>

<ul>
	<li>Anticoagulants are used to treat acute thrombotic events and prevent recurrent venous blood clots. They may be given for years<a href="#accordion">[4]</a>.</li>
	<li>Platelet inhibitors, such as aspirin and clopidogrel, are used to prevent recurrences of arterial events in patients with anti-phospholipid autoantibodies (aPL)<a href="#accordion">[4]</a>.</li>
	<li>Subcutaneous injections of heparin and low-dose aspirin are the standard therapy to prevent miscarriages in pregnant women with aPL<a href="#accordion">[4]</a>.</li>
	<li>Additional therapies, such as IVIG infusions and corticosteroids, may be needed in more difficult pregnancy-related cases. Pregnant women who previously had blood clots may receive the same combination of heparin and aspirin, but with higher heparin doses, to prevent blood clots<a href="#accordion">[4]</a>.</li>
</ul>

Treatment is generally not necessary if no additional risk factors for clotting or an associated autoimmune disease are present in patients with aPL and no prior thrombotic events or miscarriages. 
&nbsp;

<h5>How To Stay Safe While Using Blood Thinners?</h5>

If you are on blood-thinning medication, you have to be extra careful to prevent injury and avoid bleeding. This includes:

<ul>
	<li>Refraining from contact sports or activities that may cause bruising or falls</li>
	<li>Using a soft toothbrush and waxed floss</li>
	<li>Shaving with an electric razor</li>
	<li>Taking extra care when handling sharp objects</li>
</ul>

Women, in particular, should steer clear of using estrogen therapy for birth control or to manage menopause. 
&nbsp;

<h5>What Food And Dietary Supplements Should I Avoid While Taking Blood Thinners?</h5>

Foods and medications can impact the effectiveness of blood thinners, so it&#39;s important to consult your healthcare provider for guidance<a href="#accordion">[2]</a>:

<ul>
	<li>You may need to limit your intake of vitamin K-rich foods, like broccoli and cabbage, if you take warfarin and avoid alcohol.</li>
	<li>Certain medications, vitamins, and herbal products can also interact dangerously with blood thinners, so it&#39;s important to discuss safe options with your healthcare provider. 
	&nbsp;</li>
</ul>

Antiphospholipid syndrome can cause several complications, such as<a href="#accordion">[2]</a>: 
&nbsp;

<ul>
	<li>Kidney failure due to reduced blood flow</li>
	<li>Paralysis and permanent neurological damage</li>
	<li>Cardiovascular issues, including damage to the valves in veins that carry blood to the heart, causing chronic swelling and discoloration in the lower legs, or even heart damage</li>
	<li>Lung problems, such as pulmonary embolism and high blood pressure in the lungs</li>
	<li>Pregnancy complications, such as miscarriages, stillbirths, premature delivery, slow fetal growth, and dangerously high blood pressure during pregnancy (preeclampsia)</li>
	<li>Rarely, in severe cases, multiple organ damage in a short time </li>
	<li>1 in 2 people die even with the best treatment due to this condition when high-dose anticoagulants are used to stop blood clots from getting bigger<a href="#accordion">[3]</a> 
	&nbsp;</li>
</ul>

Conclusion

Antiphospholipid syndrome is a rare autoimmune disorder that is characterized by the presence of antiphospholipid antibodies in the blood. These antibodies can interfere with the body&#39;s ability to prevent blood clots, which can lead to a range of health complications. 

The most common complications of the antiphospholipid syndrome include thrombosis (blood clots) and pregnancy-related problems, such as miscarriage, stillbirth, and preeclampsia. Other complications can include kidney failure, stroke, cardiovascular problems, and lung problems.

While there is no cure for antiphospholipid syndrome, prompt diagnosis, and appropriate management can help prevent or minimize the damage caused by this disorder. It is important for individuals with the antiphospholipid syndrome to work closely with their healthcare providers to monitor their condition and manage their symptoms to reduce the risk of complications. 
&nbsp;

Key Takeaways

<ul>
	<li>Antiphospholipid syndrome is characterized by a heightened propensity to form blood clots (thromboses) in the bloodstream.</li>
	<li>This tendency towards blood clotting, referred to as thrombophilia, can result in the formation of clots in various blood vessels throughout the body.</li>
	<li>This disorder is considered to be an autoimmune condition where the immune system mistakenly attacks the body&#39;s own tissues and organs.</li>
	<li>Antiphospholipid syndrome is a relatively uncommon condition that is estimated to affect about 1 in 2,000 individuals. </li>
	<li>It appears to affect women more frequently than men, with approximately 70% of those diagnosed with the condition being female.</li>
	<li>The classification of APS is primarily based on a set of clinical criteria used in the diagnosis of the disorder: primary, secondary, and catastrophic.</li>
	<li>The primary clinical consequence of antiphospholipid syndrome is a tendency to both venous and arterial thrombosis. However, thrombotic events in a specific patient with APS tend to segregate into venous or arterial.</li>
</ul>

Trusted By