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Novel Drug Targets Discovered For PCOS Therapy

Humza Khizer

Overview

With a prevalence of 8-13%, polycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting women of reproductive age<a href="#accordion">[1]</a>. Certain ethnicities are at a higher risk, such as South Asian women. As per research, Pakistani women have a higher prevalence (52%) than Western Caucasian women, e.g., 20-25% in the UK<a href="#accordion">[2]</a>.

This chronic condition leads to hormonal imbalances, irregular menstrual cycles, heightened androgen levels, and the formation of cysts on the ovaries. The irregular periods, often accompanied by an absence of ovulation, can hinder fertility, rendering PCOS a primary cause of infertility. 
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Symptoms of PCOS vary from person to person and may evolve over time, often manifesting without a clear trigger. These symptoms encompass irregular, heavy, or absent menstrual periods, acne, excessive facial or body hair growth, hair thinning or baldness, and weight gain&mdash;especially around the abdominal area. The physical and emotional repercussions of PCOS, particularly in relation to obesity, self-image, and difficulties in conceiving, can lead to mental health struggles and societal stigmatization.

The current treatments for PCOS often focus on symptom management, leaving an unmet need for a comprehensive and targeted approach that tackles the root causes of this condition. Enter Celmatix, a pioneering force in women&#39;s health biotechnology, unveiling a revolutionary drug program that aims to address PCOS at its core.&nbsp;&nbsp; 
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Understanding the PCOS Therapy

Celmatix has unveiled a groundbreaking drug program aimed at addressing PCOS. The novel drug program targets melatonin receptors found outside the central nervous system (CNS)<a href="#accordion">[3]</a>.

Melatonin, a hormone known for regulating the sleep-wake cycle, has been discovered to play a crucial role in ovarian health. While melatonin supplements have shown potential benefits for women&#39;s health, their limited effectiveness and unwanted side effects have prompted Celmatix to pioneer a more focused approach.

This groundbreaking program emerged from a comprehensive exploration of the molecular and genetic factors underlying ovarian health and PCOS. Celmatix&#39;s research identified rare genetic mutations in melatonin receptor genes among women with PCOS, indicating a strong connection between these genes and PCOS traits.

By developing a novel melatonin receptor agonist compound, Celmatix aims to enhance therapeutic action in target tissues, such as the ovary, while minimizing side effects like drowsiness. Moreover, the novel drug holds promise of supporting ovarian health throughout a woman&rsquo;s life. This includes treating PCOS early in life and then helping menopausal women overcome the changes of declining ovarian health.

This visionary program not only holds the potential to alleviate the complex challenges posed by PCOS but also lays the foundation for a transformative approach to women&#39;s health. As Celmatix continues to lead the way in advancing fertility and reproductive solutions, their novel drug program marks a significant step towards empowering women to lead healthier lives and realize their dreams of parenthood. 
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Conclusion

This visionary program not only holds the potential to alleviate the complex challenges posed by PCOS but also lays the foundation for a transformative approach to women&#39;s health. As Celmatix continues to lead the way in advancing fertility and reproductive solutions, their novel drug program marks a significant step towards empowering women to lead healthier lives and realize their dreams of parenthood. 
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Key Points

<ul>
	<li>PCOS (polycystic ovary syndrome) is a common endocrine disorder affecting 8-13% of women of reproductive age, with higher prevalence in certain ethnicities like South Asian women.</li>
	<li>PCOS leads to hormonal imbalances, irregular menstrual cycles, excess androgen levels, and ovarian cysts, causing infertility.</li>
	<li>Symptoms of PCOS include irregular periods, acne, excessive hair growth, hair thinning, baldness, and weight gain, impacting both physical and emotional well-being.</li>
	<li>Current PCOS treatments focus on symptom management, leaving a need for a comprehensive approach targeting root causes.</li>
	<li>Celmatix&#39;s groundbreaking drug program targets melatonin receptors outside the CNS, aiming to address PCOS at its core.</li>
	<li>Melatonin, known for sleep regulation, plays a vital role in ovarian health, but supplements have limitations.</li>
	<li>Celmatix&#39;s program emerged from research identifying rare genetic mutations in melatonin receptor genes among women with PCOS.</li>
	<li>The program develops a novel melatonin receptor agonist compound to enhance therapeutic action in target tissues, minimizing side effects.</li>
	<li>Celmatix&#39;s program envisions supporting ovarian health throughout a woman&rsquo;s life, from treating PCOS to aiding menopausal changes.</li>
	<li>This transformative program could revolutionize women&#39;s health, empower healthier lives, and fulfill dreams of parenthood.</li>
</ul>

[1] Polycystic Ovary Syndrome. World Health Organization.

[2] Sidra S, Tariq MH, Farrukh MJ, Mohsin M (2019) Evaluation of clinical manifestations, health risks, and quality of life among women with polycystic ovary syndrome. PLoS ONE 14(10): e0223329. DOI:10.1371/journal.pone.0223329